STRUCTURE OF A MUTANT OF TYROSYL-TRANSFER RNA-SYNTHETASE WITH ENHANCED CATALYTIC PROPERTIES

被引:27
作者
BROWN, KA [1 ]
BRICK, P [1 ]
BLOW, DM [1 ]
机构
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,BLACKETT LAB,LONDON SW7 2BZ,ENGLAND
关键词
D O I
10.1038/326416a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:416 / 418
页数:3
相关论文
共 18 条
[1]   TYROSYL-TRANSFER RNA-SYNTHETASE FORMS A MONONUCLEOTIDE-BINDING FOLD [J].
BHAT, TN ;
BLOW, DM ;
BRICK, P ;
NYBORG, J .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 158 (04) :699-709
[2]   CRYSTAL-STRUCTURE OF A DELETION MUTANT OF A TYROSYL-TRANSFER RNA-SYNTHETASE COMPLEXED WITH TYROSINE [J].
BRICK, P ;
BLOW, DM .
JOURNAL OF MOLECULAR BIOLOGY, 1987, 194 (02) :287-297
[3]   THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS) [J].
CARTER, PJ ;
WINTER, G ;
WILKINSON, AJ ;
FERSHT, AR .
CELL, 1984, 38 (03) :835-840
[4]   SOLVENT-ACCESSIBLE SURFACES OF PROTEINS AND NUCLEIC-ACIDS [J].
CONNOLLY, ML .
SCIENCE, 1983, 221 (4612) :709-713
[5]   FINE-STRUCTURE ACTIVITY ANALYSIS OF MUTATIONS AT POSITION 51 OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].
FERSHT, AR ;
WILKINSON, AJ ;
CARTER, P ;
WINTER, G .
BIOCHEMISTRY, 1985, 24 (21) :5858-5861
[6]   HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
KNILLJONES, J ;
LOWE, DM ;
WILKINSON, AJ ;
BLOW, DM ;
BRICK, P ;
CARTER, P ;
WAYE, MMY ;
WINTER, G .
NATURE, 1985, 314 (6008) :235-238
[7]   DEMONSTRATION OF 2 REACTION PATHWAYS FOR AMINOACYLATION OF TRANSFER-RNA - APPLICATION OF PULSED QUENCHED FLOW TECHNIQUE [J].
FERSHT, AR ;
JAKES, R .
BIOCHEMISTRY, 1975, 14 (15) :3350-3356
[8]   COMPUTER-SIMULATION OF AQUEOUS BIOMOLECULAR SYSTEMS [J].
FINNEY, JL ;
GOODFELLOW, JM ;
HOWELL, PL ;
VOVELLE, F .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1985, 3 (03) :599-622
[9]   INTERNAL THERMODYNAMICS OF POSITION 51 MUTANTS AND NATURAL VARIANTS OF TYROSYL-TRANSFER RNA-SYNTHETASE [J].
HO, CK ;
FERSHT, AR .
BIOCHEMISTRY, 1986, 25 (08) :1891-1897
[10]   INTERPRETATION OF PROTEIN STRUCTURES - ESTIMATION OF STATIC ACCESSIBILITY [J].
LEE, B ;
RICHARDS, FM .
JOURNAL OF MOLECULAR BIOLOGY, 1971, 55 (03) :379-&