ENTORHINAL CORTEX LONG-TERM POTENTIATION EVOKED BY THETA-PATTERNED STIMULATION OF ASSOCIATIVE FIBERS IN THE ISOLATED INVITRO GUINEA-PIG BRAIN

被引：24
作者：
DECURTIS, M
LLINAS, RR
机构：
[1] NYU,DEPT PHYSIOL & BIOPHYS,550 1ST AVE,NEW YORK,NY 10016
[2] IST NAZL NEUROL,DIPARTIMENTO NEUROFISIOL,MILAN,ITALY
来源：
BRAIN RESEARCH | 1993年 / 600卷 / 02期
关键词：
ISOLATED BRAIN INVITRO; ENTORHINAL CORTEX; LONG-TERM POTENTIATION; NMDA RECEPTOR;
D O I：
10.1016/0006-8993(93)91391-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) induced in the lateral entorhinal cortex by theta-patterned tetanic stimulation of the piriform cortex was analyzed in the isolated guinea pig brain maintained in vitro. Monosynaptic excitatory postsynaptic potentials (EPSPs) evoked by stimulation of the piriform cortex are composed of an early and late component selectively blocked by non-N-methyl-D-aspartate (non-NMDA) and NMDA receptor antagonists, respectively. LTP induction was dependent on NMDA receptor activation, being blocked by perfusing the preparation with 2-amino-5-phosphonovalerate (AP-5). LTP was expressed through synaptic enhancement of both early non-NMDA and late, possibly NMDA receptor-mediated responses.
引用
收藏
页码：327 / 330
页数：4
相关论文
共 11 条
[1]   POSTSYNAPTIC HEBBIAN AND NON-HEBBIAN LONG-TERM POTENTIATION OF SYNAPTIC EFFICACY IN THE ENTORHINAL CORTEX IN SLICES AND IN THE ISOLATED ADULT GUINEA-PIG BRAIN [J].
ALONSO, A ;
DECURTIS, M ;
LLINAS, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (23) :9280-9284
[2]   THE INVOLVEMENT OF N-METHYL-D-ASPARTATE RECEPTORS IN INDUCTION AND MAINTENANCE OF LONG-TERM POTENTIATION IN RAT VISUAL-CORTEX [J].
ARTOLA, A ;
SINGER, W .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1990, 2 (03) :254-269
[3]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[4]  
DECURTIS M, 1991, HIPPOCAMPUS, V1, P163
[5]  
DECURTIS M, 1991, SOC NEUR ABSTR, P21
[6]   PROJECTIONS FROM AMYGDALOID COMPLEX AND ADJACENT OLFACTORY STRUCTURES TO ENTORHINAL CORTEX AND TO SUBICULUM IN RAT AND CAT [J].
KRETTEK, JE ;
PRICE, JL .
JOURNAL OF COMPARATIVE NEUROLOGY, 1977, 172 (04) :723-752
[7]  
LLINAS RR, 1989, J PHYSL, V408, pP17
[8]   MECHANISMS UNDERLYING LONG-TERM POTENTIATION OF SYNAPTIC TRANSMISSION [J].
MADISON, DV ;
MALENKA, RC ;
NICOLL, RA .
ANNUAL REVIEW OF NEUROSCIENCE, 1991, 14 :379-397
[9]   STABLE HIPPOCAMPAL LONG-TERM POTENTIATION ELICITED BY THETA-PATTERN STIMULATION [J].
STAUBLI, U ;
LYNCH, G .
BRAIN RESEARCH, 1987, 435 (1-2) :227-234
[10]   SYNAPTIC ORGANIZATION OF OLFACTORY INPUTS AND LOCAL CIRCUITS IN THE ENTORHINAL CORTEX - A CURRENT SOURCE DENSITY ANALYSIS IN THE CAT [J].
VANGROEN, T ;
DASILVA, FHL ;
WADMAN, WJ .
EXPERIMENTAL BRAIN RESEARCH, 1987, 67 (03) :615-622
12