ANTIRETROVIRAL THERAPY IN SPORADIC ADULT AMYOTROPHIC-LATERAL-SCLEROSIS

被引：23

作者：

WESTARP, ME

BARTMANN, P

ROSSLER, J

GEIGER, E

WESTPHAL, KP

SCHREIBER, H

FUCHS, D

WESTARP, MP

KORNHUBER, HH

机构：

[1] UNIV ULM, DEPT PEDIAT, W-7900 ULM, GERMANY

[2] GERMAN CANC RES CTR, W-6900 HEIDELBERG, GERMANY

[3] INST MED CHEM & BIOCHEM, A-6020 INNSBRUCK, AUSTRIA

[4] LUDWIG BOLTZMANN INST AIDS RES, A-6020 INNSBRUCK, AUSTRIA

来源：

NEUROREPORT | 1993年 / 4卷 / 06期

关键词：

AMYOTROPHIC LATERAL SCLEROSIS; ANTIRETROVIRAL THERAPY; HUMAN FOAMY VIRUS (HFV); HUMAN SPUMA RETROVIRUS (HSRV); RETROVIRIDAE; ZIDOVUDINE (RETROVIR(R));

D O I：

10.1097/00001756-199306000-00056

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CLINICAL and experimental findings in idiopathic amyothrophic lateral sclerosis (ALS) would be compatible with a retroviral involvement. In 35 adult patients with non-familial ALS we observed elevated circulating immune complexes, a decrease in IgG3 isotype and enzyme-linked sorbent assay (ELISA) serum antibodies against human spuma retrovirus (HSRV), confirmed by specific human foamy virus immunoblots. All 35 were negative for IgM or relevant IgG anti-ganglioside antibodies. We treated 12 HIV-negative, immune-complex-positive ALS patients with 500 mg d-1 zidovudine p.o. over 2-10 months and found reductions of serum creatine kinase and circulating immune complexes from two days to two weeks after the beginning of medication.

引用

页码：819 / 822

页数：4

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