PHYSICAL MAPPING OF THE HUMAN CARBONIC-ANHYDRASE GENE-CLUSTER ON CHROMOSOME 8

被引：16

作者：

LOWE, N ^{[1
]}

EDWARDS, YH ^{[1
]}

EDWARDS, M ^{[1
]}

BUTTERWORTH, PHW ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL, MRC, GALTON LAB, HUMAN BIOCHEM GENET UNIT, LONDON NW1 2HE, ENGLAND

来源：

GENOMICS | 1991年 / 10卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0888-7543(91)90176-F

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A cluster of genes encoding the three cytoplasmic carbonic anhydrase isozymes CAI, CAII, and CAIII lie on the long arm of chromosome 8 (8q22) in humans. These genes have been mapped using pulsed-field gel electrophoresis. The genes lie in the order CA2, CA3, CA1. CA2 and CA3 are separated by 20 kb and are transcribed in the same direction, away from CA1. CA1 is separated from CA3 by over 80 kb and is transcribed in the direction opposite to CA2 and CA3. The arrangement of the genes is consistent with proposals that the duplication event which gave rise to CA1 predated the duplication which gave rise to CA2 and CA3. The order of these three genes differs from that suggested for the mouse based on recombination frequency. © 1991.

引用

页码：882 / 888

页数：7

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