RESPONSE OF CEREBRAL BLOOD-VOLUME TO CHANGES IN ARTERIAL CARBON-DIOXIDE TENSION IN PRETERM AND TERM INFANTS

被引：171

作者：

WYATT, JS ^{[1
]}

EDWARDS, AD ^{[1
]}

COPE, M ^{[1
]}

DELPY, DT ^{[1
]}

MCCORMICK, DC ^{[1
]}

POTTER, A ^{[1
]}

REYNOLDS, EOR ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL, DEPT MED PHYS & BIOENGN, LONDON WC1E 6JJ, ENGLAND

来源：

PEDIATRIC RESEARCH | 1991年 / 29卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1203/00006450-199106010-00007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The response of cerebral blood volume (CBVR) to a small induced change in arterial carbon dioxide tension was studied by near-infrared spectroscopy in 17 newborn infants born from 26 wk of gestation to term. All 17 infants were undergoing mechanical ventilation but had apparently normal brains. The CBVR per kPa change in arterial carbon dioxide tension within the range 3.9 to 9.6 kPa was calculated from the change in total cerebral Hb concentration ([TCHb]) using the equation: DELTA-CBV = DELTA[TCHb] x 0.89/[H] where [H] is the large vessel Hb concentration. A least-squares regression line with 95% confidence limits was derived for CBVR against gestational age. A highly significant linear increase in CBVR was found: mean CBVR from the regression increased from 0.07 mL.100 g-1.kPa-1 at 26 wk to 0.51 mL.100 g-1. kPa-1 at 40 wk.

引用

页码：553 / 557

页数：5

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