A database for the predicted pharmacophoric features of medicinal compounds

被引：20

作者：

Daisy, Pitchai ^{[1
]}

Singh, Sanjeev Kumar ^{[2
]}

Vijayalakshmi, Periyasamy ^{[1
]}

Selvaraj, Chandrabose ^{[2
]}

Rajalakshmi, Manikkam ^{[1
]}

Suveena, Sukumaran ^{[1
]}

机构：

[1] Holy Cross Coll Autonomous, Res Dept Biotechnol & Bioinformat, Bioinformat Ctr BIF, PG, Tiruchirappalli 620002, Tamil Nadu, India

[2] Alagappa Univ, Dept Bioinformat, Comp Aided Drug Design & Mol Modeling Lab, Karaikkudi 630003, Tamil Nadu, India

来源：

BIOINFORMATION | 2011年 / 6卷 / 04期

关键词：

Anti Diabetic; Anti Cancer; Anti Microbial; Pharmacophoric features; Phase;

D O I：

10.6026/97320630006167

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pharmacophore feature is defined by a set of chemical structure patterns having the active site of drug like molecule. Pharmacophore can be used to assist in building hypothesis about desirable chemical properties in drug molecule and hence it can be used to refine and modify drug candidates. We predicted the pharmacophoric features of 150 medicinal compounds from plants for anti-cancer, anti-carcinogenic, anti-diabetic, anti-microbial, and anti-oxidant. Estimation of pharmacophoric feature is necessary to ensure the optimal supramolecular interaction with a biological target and to trigger or block its biological response.

引用

页码：167 / 168

页数：2

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