POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOG

被引：10783

作者：

ZHANG, YY

PROENCA, R

MAFFEI, M

BARONE, M

LEOPOLD, L

FRIEDMAN, JM

机构：

[1] HOWARD HUGHES MED INST,NEW YORK,NY 10021

[2] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

NATURE | 1994年 / 372卷 / 6505期

关键词：

D O I：

10.1038/372425a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.

引用

页码：425 / 432

页数：8

共 49 条

[1] URGES TO EAT AND DRINK IN RATS [J].