CARBOPLATIN OTOTOXICITY IN HEAD AND NECK-CANCER PATIENTS

被引：12
|
作者：
BAUER, FP
WESTHOFEN, M
KEHRL, W
机构：
来源：
LARYNGO-RHINO-OTOLOGIE | 1992年 / 71卷 / 08期
关键词：
CARBOPLATIN; OTOTOXICITY; HEAD AND NECK CANCER PATIENTS;
D O I：
10.1055/s-2007-997325
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
The side effects of the anti-cancer drug carboplatin on the cochlea in 65 patients with head and neck cancer were examined in the present study. A possible dependence of ototoxicity on the patient's age, the effect of pre-existing audiometric changes and the carboplatin dose were investigated. A therapy-induced sensory hearing loss was found in 32% of the patients. The average hearing loss was 15 dB and primarily involved the frequency ranges from 4 to 8 kHz. The degree of the hearing defects incurred was not influenced by the patient's age or pre-existing hearing defects but depended on the carboplatin dose used. The severity of carboplatin cochlear ototoxicity was moderate, so that no patient suffered a lack of hearing that was of social significance.
引用
收藏
页码：412 / 415
页数：4
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