HIGH-DOSE EPINEPHRINE ACTS AT ALPHA-2-ADRENOCEPTORS TO SUPPRESS EXPERIMENTAL ARTHRITIS

被引:26
作者
CODERRE, TJ
BASBAUM, AI
HELMS, C
LEVINE, JD
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT MED,DIV RHEUMATOL,BOX 0724,RM U-426,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT ANAT,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,DEPT RADIOL,SAN FRANCISCO,CA 94143
[4] UNIV CALIF SAN FRANCISCO,DIV NEUROBIOL,SAN FRANCISCO,CA 94143
关键词
ARTHRITIS; EPINEPHRINE; SYMPATHETIC NEURON; ADRENOCEPTOR; NEUROGENIC INFLAMMATION;
D O I
10.1016/0006-8993(91)90073-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study assessed the receptor site at which high systemic doses of epinephrine act to reduce the severity of adjuvant-induced arthritis in the rat. To this end we examined the effect of selective adrenergic antagonists on the reduction of arthritis by epinephrine, and also assessed whether high doses of selective adrenergic agonists mimicked the effect of epinephrine. The decrease in arthritis induced by epinephrine (0.5 mg/kg in chronic implant injected every 3 days) was significantly antagonized by the selective alpha-2-adrenergic antagonist, yohimbine, but not by selective alpha-1 (prazosin), beta-1 (metoprolol) or beta-2 (butoxamine) antagonists. In addition, chronic infusion of the alpha-2-adrenergic agonist clonidine, but not selective alpha-1 (phenylephrine), beta-1/beta-2 (isoproterenol) or beta-2 (salbutamol) agonists, resulted in decreased arthritis severity. These data suggest that the suppressive effect of high-dose epinephrine on joint injury in experimental arthritis is mediated by action at the alpha-2-adrenergic receptor.
引用
收藏
页码:325 / 328
页数:4
相关论文
共 12 条
[1]   EFFECTS OF NAPROXEN ON CONNECTIVE-TISSUE CHANGES IN THE ADJUVANT ARTHRITIC RAT [J].
ACKERMAN, NR ;
ROOKS, WH ;
SHOTT, L ;
GENANT, H ;
MALONEY, P ;
WEST, E .
ARTHRITIS AND RHEUMATISM, 1979, 22 (12) :1365-1374
[2]   ADRENALINE AND THE DEVELOPMENT OF SPONTANEOUS HYPERTENSION IN RATS [J].
BORKOWSKI, KR ;
QUINN, P .
JOURNAL OF AUTONOMIC PHARMACOLOGY, 1985, 5 (02) :89-100
[3]   EPINEPHRINE EXACERBATES ARTHRITIS BY AN ACTION AT PRESYNAPTIC B2-ADRENOCEPTORS [J].
CODERRE, TJ ;
BASBAUM, AI ;
DALLMAN, MF ;
HELMS, C ;
LEVINE, JD .
NEUROSCIENCE, 1990, 34 (02) :521-523
[4]  
CODERRE TJ, IN PRESS NEUROSCIENC
[5]   BETA-2-ADRENERGIC MECHANISMS IN EXPERIMENTAL ARTHRITIS [J].
LEVINE, JD ;
CODERRE, TJ ;
HELMS, C ;
BASBAUM, AI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4553-4556
[6]  
LEVINE JD, 1986, J NEUROSCI, V6, P3423
[7]  
PEARSON CM, 1959, ARTHRITIS RHEUM, V2, P440, DOI 10.1002/1529-0131(195910)2:5<440::AID-ART1780020510>3.0.CO
[8]  
2-N
[9]  
STJARNE L, 1975, Naunyn-Schmiedeberg's Archives of Pharmacology, V288, P295
[10]  
STJARNE L, 1975, ACTA PHYSIOL SCAND, V94, P139