Idiopathic scoliosis: etiological concepts and hypotheses

被引：38

作者：

Dayer, Romain ^{[1
]}

Haumont, Thierry ^{[2
]}

Belaieff, Wilson ^{[1
]}

Lascombes, Pierre ^{[1
,2
]}

机构：

[1] Univ Hosp Geneva, Dept Pediat Orthopaed, Child & Adolescent Dept, Rue Willy Donze 6, CH-1211 Geneva 14, Switzerland

[2] Univ Hosp Nancy, Childrens Hosp, Dept Pediat Orthopaed Surg, Nancy, France

来源：

JOURNAL OF CHILDRENS ORTHOPAEDICS | 2013年 / 7卷 / 01期

关键词：

Adolescent idiopathic scoliosis; Etiopathogenesis; Genetics; Molecular biology; Biomechanics; Neurology;

D O I：

10.1007/s11832-012-0458-3

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Scoliosis is diagnosed as idiopathic in 70 % of structural deformities affecting the spine in children and adolescents, probably reflecting our current misunderstanding of this disease. By definition, a structural scoliosis should be the result of some primary disorder. The goal of this article is to give a comprehensive overview of the currently proposed etiological concepts in idiopathic scoliosis regarding genetics, molecular biology, biomechanics, and neurology, with particular emphasis on adolescent idiopathic scoliosis (AIS). Despite the fact that numerous potential etiologies for idiopathic scoliosis have been formulated, the primary etiology of AIS remains unknown. Beyond etiology, identification of prognostic factors of AIS progression would probably be more relevant in our daily practice, with the hope of reducing repetitive exposure to radiation, unnecessary brace treatments, psychological implications, and costs-of-care related to follow-up in low-risk patients.

引用

页码：11 / 16

页数：6

共 67 条

[31] Platelet calmodulin levels in adolescent idiopathic scoliosis - Do the levels correlate with curve progression and severity? [J].