A NOVEL METHOD FOR THE SYNTHESIS OF ISOCYANATES UNDER MILD CONDITIONS

被引：148
作者：
KNOLKER, HJ
BRAXMEIER, T
SCHLECHTINGEN, G
机构：
[1] Institut für Organische Chemie, Universität Karlsruhe, D-76131, Richard‐Willstätter‐Allee
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 22期
关键词：
ARENES; DI-TERT-BUTYL DICARBONATE; ISOCYANATES;
D O I：
10.1002/anie.199524971
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Not the amine‐N‐Boc derivatives, but the isocyanates form in the reaction of alkyl‐ or arylamines with di‐tert‐butyl dicarbonate ((Boc)2O) in the presence of a catalytic amount of 4‐dimethylaminopyridine (DMAP) according to Equation (a). The procedure provides a simple laboratory method of generating sterically hindered alkyl and aryl isocyanates without the use of phosgene. (Formula Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany
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页码：2497 / 2500
页数：4
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