AN OBJECTIVE METHOD TO RECORD CHANGES IN NASAL REACTIVITY DURING TREATMENT OF NONALLERGIC NASAL HYPERREACTIVITY

被引：9
作者：
HALLEN, H
JUTO, JE
机构：
[1] Department of Otorhinolaryngology at Karolinska Institute, Stockholm, Sodersjukhuset
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1994年 / 56卷 / 02期
关键词：
NONALLERGIC NASAL HYPERREACTIVITY; INTRANASAL STEROIDS; HISTAMINE PROVOCATION; RHINOSTEREOMETRY;
D O I：
10.1159/000276617
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Non-allergic nasal hyperreactivity is a common problem and many patients suffer from daily symptoms demanding medication. Hitherto there exists no objective method to study congestional changes in clinical practice, to evaluate the efficacy of different therapies. This study is an attempt to develop a method for this purpose. Eleven patients with non-allergic nasal hyperreactivity entered the trial. A histamine challenge model with three different histamine concentrations was used. Recordings of the reactivity of the nasal mucosa were made with rhinostereometry before and after 14 days of topical treatment with budesonide 200 mu g/day. The results were compared to symptom scores before and after treatment. It was found that there was a significant improvement after treatment both with regard to symptom score and to the recorded reactivity of the nasal mucosa. There was a correlation between symptom score and recorded reactivity before treatment, but not after treatment. The results indicate that the symptom score technique is sufficient in situations where only a semiquantitative method is required. However, when studying changes in the degree of hyperreactivity, the demands for an objective measuring method is greater. The study indicates that the presented method may be adapted for this purpose.
引用
收藏
页码：92 / 95
页数：4
相关论文
共 13 条
  • [1] Jessen M., Janzon L., Prevalence of non-allergic nasal complaints in an urban and a rural population in Sweden, Allergy, 44, pp. 582-587, (1989)
  • [2] Mygind N., Perennial rhinitis I, Essential Allergy, 75, (1986)
  • [3] Van Gerth Wijk R., Nasal hyperreactivity its pathogenesis and clinical significance, Clin Exp Allergy, 21, pp. 661-667, (1991)
  • [4] Hallen H., Juto J.-E., Correlation between Subjective and Objective Assessment of Nasal Hyperreactivity
  • [5] Malm L., Wihl J., Beclomethasonc diproprionate in vasomotor rhinitis, Acta Allergol, 31, pp. 245-253, (1976)
  • [6] Lofkvist T., Svensson G., Treatment of vasomotor rhinitis with intranasal beclomethasone dipropionate, Acta Allergol, 31, pp. 227-238, (1976)
  • [7] Balle V.H., Pedersen U., Engby B., Allergic perennial and non-allergic, vasomotor rhinitis treated with budesonide nasal spray, Rhinology, 18, pp. 135-142, (1980)
  • [8] Juto J.E., Lundberg C., An optical method to determine changes in mucosal congestion in the nose in man, Acta Otolaryngol (Stockh), 94, (1982)
  • [9] Juto J.E., Rhinostereometry, (1985)
  • [10] Balle V., Pedersen U., Engby B., The treatment of perennial rhinitis with a new non-halogenated drug, topical, aerosol packed, steroid, budesonide, Acta Otolaryngol (Stockh), 94, pp. 169-173, (1982)
12