CAN SOLUBLE-ANTIGENS INDUCE CD8+ CYTOTOXIC T-CELL RESPONSES - A PARADOX REVISITED

被引：68
作者：
RAYCHAUDHURI, S [1 ]
MORROW, WJW [1 ]
机构：
[1] ST BARTHOLOMEWS HOSP, DEPT IMMUNOL, LONDON EC1A 7BE, ENGLAND
来源：
IMMUNOLOGY TODAY | 1993年 / 14卷 / 07期
关键词：
D O I：
10.1016/0167-5699(93)90233-B
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cytotoxic T lymphocyte (CTL) induction usually follows processing of antigens via endogenous pathways before presentation on the cell surface in association with MHC class I molecules. Soluble antigens do not, in general, induce specific CTL responses. Here, Syamal Raychaudhuri and John Morrow suggest that a novel adjuvant formulation can elicit CTL responses to soluble antigens and discuss the implications for vaccine development.
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页码：344 / 348
页数：5
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