THRESHOLD FOR INHIBITION OF NA, K-ATPASE BY ELF ALTERNATING CURRENTS

被引：45

作者：

BLANK, M

SOO, L

机构：

[1] Department of Physiology and Cellular Biophysics, Columbia University, New York, New York

来源：

BIOELECTROMAGNETICS | 1992年 / 13卷 / 04期

关键词：

ENZYME FUNCTION; MEMBRANE PROTEIN; ION PUMP; ELECTRIC FIELD;

D O I：

10.1002/bem.2250130409

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alternating currents can increase or decrease the ATP-splitting activity of the membrane enzyme Na,K-ATPase. Either change depends on the AC frequency, and the greatest effect appears to be in the ELF range at about 100 Hz. The threshold for enzyme inhibition by AC was determined, and it is estimated to be an internal electric field circa 5-mu-V/cm. The corresponding current-density threshold approximates 8 nA/cm2.

引用

页码：329 / 333

页数：5

共 8 条

[1]

ARIENS EJ, 1964, MOL PHARM, P119

[2] NA,K-ATPASE FUNCTION IN ALTERNATING ELECTRIC-FIELDS [J].