TEMPERATURE-SENSITIVE VARIANTS OF HISTOPLASMA-CAPSULATUM ISOLATED FROM PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME

被引：49
作者：
SPITZER, ED
KEATH, EJ
TRAVIS, SJ
PAINTER, AA
KOBAYASHI, GS
MEDOFF, G
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT MED,DIV INFECT DIS,BOX 8051,660 S EUCLID AVE,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT MED,DIV LAB MED,ST LOUIS,MO 63110
[3] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
来源：
JOURNAL OF INFECTIOUS DISEASES | 1990年 / 162卷 / 01期
关键词：
D O I：
10.1093/infdis/162.1.258
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Histoplasma capsulatum isolates from three St. Louis area AIDS patients with disseminated histoplasmosis were found to be closely related to the temperature-sensitive, previously unique, Downs strain based on growth phenotype and restriction fragment length polymorphisms (RFLP) involving mitochondrial DNA, ribosomal DNA, and the yps-3 gene. H. capsulatum isolates from five non-AIDS patients in the St. Louis area with disseminated histoplasmosis or chronic pulmonary histoplasmosis had the growth phenotype and RFLP pattern characteristic of most strains isolated from other regions of the USA. © 1990 by The University of Chicago.
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页码：258 / 261
页数：4
相关论文
共 15 条
[1]   EMERGING PATTERN OF URBAN HISTOPLASMOSIS - STUDIES ON AN EPIDEMIC IN MEXICO, MISSOURI [J].
FURCOLOW, ML ;
LARSH, HW ;
SHAW, G ;
LYNCH, HJ ;
TOSH, FE .
NEW ENGLAND JOURNAL OF MEDICINE, 1961, 264 (24) :1226-&
[2]   HISTOPLASMOSIS - AN ILLUSTRATIVE CASE WITH UNUSUAL VAGINAL AND JOINT INVOLVEMENT [J].
GASS, M ;
KOBAYASHI, GS .
ARCHIVES OF DERMATOLOGY, 1969, 100 (06) :724-+
[3]   INFECTIOUS COMPLICATIONS IN PATIENTS WITH HIV INFECTION [J].
GOLD, JWM .
AIDS, 1988, 2 (05) :327-334
[4]   HISTOPLASMOSIS AND AIDS [J].
GRAYBILL, JR .
JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (03) :623-626
[5]  
HAMPSON SJ, 1989, LANCET, V1, P65
[6]  
JOHNSON PC, 1988, AM J MED, V85, P152, DOI 10.1016/S0002-9343(88)80334-6
[7]   VARIABLE EXPRESSION OF A YEAST-PHASE-SPECIFIC GENE IN HISTOPLASMA-CAPSULATUM STRAINS DIFFERING IN THERMOTOLERANCE AND VIRULENCE [J].
KEATH, EJ ;
PAINTER, AA ;
KOBAYASHI, GS ;
MEDOFF, G .
INFECTION AND IMMUNITY, 1989, 57 (05) :1384-1390
[8]  
LASKER BA, 1987, P ANN M AM SOC MICRO
[9]   IRREVERSIBLE BLOCK OF THE MYCELIAL-TO-YEAST PHASE-TRANSITION OF HISTOPLASMA-CAPSULATUM [J].
MEDOFF, G ;
SACCO, M ;
MARESCA, B ;
SCHLESSINGER, D ;
PAINTER, A ;
KOBAYASHI, GS ;
CARRATU, L .
SCIENCE, 1986, 231 (4737) :476-479
[10]   CORRELATION BETWEEN PATHOGENICITY AND TEMPERATURE SENSITIVITY IN DIFFERENT STRAINS OF HISTOPLASMA-CAPSULATUM [J].
MEDOFF, G ;
MARESCA, B ;
LAMBOWITZ, AM ;
KOBAYASHI, G ;
PAINTER, A ;
SACCO, M ;
CARRATU, L .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (06) :1638-1647
12