LUNG TUMOR INCIDENCE IN MICE TREATED WITH HYDRAZINE SULFATE

Lung tumor incidence in mice fed hydrazine sulfate (1.1 mg/day per mouse) was studied in male and female mice of Swiss, Strong A and F1 cross of ICRC (female) .times. C3H (Jax) (male), as well as in C17 males. Swiss mice showed 100% lung adenocarcinomas. None of the treated mice of different strains had liver tumors. Hydrazine sulfate also induced adenocarcinomas of lung in Strong A and F1 cross of ICRC females .times. C3H (Jax) males, but it produced lymphomas of the lung in the C17 strain. Female mice of Swiss strain and F1 hybrids showed greater susceptibility to hydrazine sulfate than the males. It was interesting to observe that protein and vitamin B deficiency in the diet shortened the tumor induction period in Swiss mice.