SELECTIVE MYCOBACTERIUM AVIUM-INDUCED PRODUCTION OF NITRIC-OXIDE BY HUMAN MONOCYTE-DERIVED MACROPHAGES

被引:63
作者
DUMAREY, CH
LABROUSSE, V
RASTOGI, N
VARGAFTIG, BB
BACHELET, M
机构
[1] INST PASTEUR,INSERM,U285,UNITE PHARMACOL CELLULAIRE,F-75724 PARIS 15,FRANCE
[2] INST PASTEUR,UNITE TB & MYCOBACTERIES,PARIS,FRANCE
关键词
NITRIC OXIDE; HUMAN MONOCYTE-DERIVED MACROPHAGES; MYCOBACTERIA; MYCOBACTERIUM-AVIUM; MYCOBACTERIUM-TUBERCULOSIS; MYCOBACTERIUM-SMEGMATIS;
D O I
10.1002/jlb.56.1.36
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Infection with a virulent strain of Mycobacterium avium, but not with virulent Mycobacterium tuberculosis or avirulent Mycobacterium smegmatis, induced the formation of nitric oxide by human monocyte-derived macrophages. This process was not affected by lipopolysaccharide or cytokines such as interferon-gamma or tumor necrosis factor alpha. M. avium-induced nitric oxide production was significantly decreased by N-G-monomethyl-L-arginine, a potent inhibitor of nitric oxide synthase activity, without any significant enhancement of intramacrophagic mycobacterial growth. Infection with all the three mycobacterial species induced a significant activation of phospholipase A(2) activity of macrophages as evidenced by the increased release of thromboxane A(2). Finally, nitric oxide production by human monocyte-derived macrophages required infection with live M. avium, as neither gamma-irradiated M. avium nor the subcellular fractions of this microorganism (cell wall, cytosol) were able to trigger nitric oxide synthesis.
引用
收藏
页码:36 / 40
页数:5
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