ANTIBODIES TO HEPATITIS-E VIRUS AMONG CHINESE PATIENTS WITH ACUTE HEPATITIS IN TAIWAN

被引:13
作者
TSAI, JF [1 ]
JENG, JE [1 ]
CHANG, WY [1 ]
LIN, ZY [1 ]
TSAI, JH [1 ]
机构
[1] KAOHSIUNG MED COLL,CLIN LAB,KAOHSIUNG,TAIWAN
关键词
ANTIBODY TO HEPATITIS E VIRUS; ANTIBODY TO HEPATITIS C VIRUS; HEPATITIS B SURFACE ANTIGEN; ACUTE HEPATITIS;
D O I
10.1002/jmv.1890430405
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The prevalence of antibodies to hepatitis E virus (anti-HEV) was investigated in patients with acute hepatitis, and correlated with the clinical features. Sera from 110 patients with acute hepatitis and 60 healthy controls were tested for anti-HEV, antibody to hepatitis C virus (anti-HCV), and hepatitis B surface antigen (HBsAg). There were significant differences in the prevalence of anti-HEV, anti-HCV, and HBsAg between patients and controls (21.8% vs. 0%, 16.3% vs. 1.6% and 58.1% vs. 18.0%, respectively). Anti-HEV was detected in 6 (25.0%) of 24 patients with anti-HCV, 6 (9.3%) of 64 patients with HBsAg, and another 6 (22.2%) of 27 patients with acute hepatitis non-A, non-B, non-C. Anti-HEV was found in 15 men and three women, whose ages ranged from 34 to 75 (median, 57) years old. The median age of patients with anti-HEV was older than that in patients without this antibody (57 vs. 38 years; P = 0.001). The prevalence of anti-HEV in patients with anti-HCV alone (35.2%) was higher than that (11.1%) in patients with HBsAg alone (P = 0.03). Compared to patients without anti-HEV, HEV-infected patients had a higher frequency of travel to a foreign country (P = 0.0001), had a lower HBsAg rate (P = 0.019), and had higher serum alkaline phosphatase levels (P = 0.04) and gamma-glutamyl transpeptidase levels (P = 0.01). In conclusion, HEV infection occurs in 22.2% of patients with acute hepatitis non-A, non-B, non-C. HEV superinfection may occur in patients with chronic hepatitis B or C virus infection. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:341 / 344
页数:4
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