INDUCTIVE TISSUE INTERACTIONS DURING INNER-EAR DEVELOPMENT

被引：13
作者：
ANNIKO, M
SCHACHT, J
机构：
[1] KAROLINSKA INST, DEPT OTORHINOLARYNGOL, S-10401 STOCKHOLM 60, SWEDEN
[2] UNIV MICHIGAN, SCH MED, KRESGE HEARING RES INST, ANN ARBOR, MI 48109 USA
[3] KAROLINSKA INST, OTOL RES LABS, S-10401 STOCKHOLM 60, SWEDEN
来源：
ARCHIVES OF OTO-RHINO-LARYNGOLOGY-ARCHIV FUR OHREN-NASEN-UND KEHLKOPFHEILKUNDE | 1984年 / 240卷 / 01期
关键词：
D O I：
10.1007/BF00464341
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Inductive tissue interactions were studied in the otocyst of the CBA/CBA mouse. Otocysts with surrounding mesenchyme explanted at the 12.5-13th gestational day and cultured in vitro for 4 days underwent morphogenesis with formation of semicircular canals, vestibular organs, and some cochlear coiling. Without their surrounding mesenchyme only little, if any, development was seen. Otocysts without mesenchyme but grown in a medium precultured with mesenchyme did develop normally. A soluble and diffusible induction factor is apparently produced by mesenchyme and also by other fetal organs. Cell-cell contact may not be needed for induction.
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页码：27 / 33
页数：7
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