PLGA-LECITHIN-PEG CORE-SHELL NANOPARTICLES FOR CANCER TARGETED THERAPY

被引：12

作者：

Zheng, Mingbin ^{[2
,3
]}

Gong, Ping ^{[1
]}

Jia, Dongxue ^{[1
]}

Zheng, Cuifang ^{[1
]}

Ma, Yifan ^{[1
]}

Cai, Lintao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen Key Lab Canc Nanotechnol, CAS Key Lab Hlth Informat, Shenzhen 518055, Peoples R China

[2] Guangdong Med Coll, Dept Chem, Dongguan 523808, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

NANO LIFE | 2012年 / 2卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Lipid-polymer nanoparticles; drug delivery; cisplatin; targeted therapy;

D O I：

10.1142/S1793984411000359

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We reported the development of multifunctional poly (lactic-co-glycolic acid) (PLGA)-lecithin-polyethylene glycol (PEG) core-shell nanoparticles (NPs) that combined the beneficial properties of liposome and polymeric NPs for chemotherapeutics delivery. The particle size, surface charge and surface functional groups were easily tunable in highly reproducible manner by various formulation parameters such as lipid/polymer, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)PEG-COOH/lecithin, DSPE-PEG-COOH/ DSPE-PEG-NH2 mass ratio and modification of terminal groups of DSPE-PEG. We encapsulated model chemotherapy drug, hydrophilic cisplatin (DDP) or hydrophobic DDP prodrug, in the NPs and showed high encapsulation efficiency, excellent stability, specific FA targeting recognition for MCF-7 cells with over FA receptors expression and pretty cytotoxicity. Such PLGA-lecithin-PEG core-shell nanoparticles (NPs) were proved to be a promising drug delivery nanocarrier for cancer-targeted therapy.

引用

页数：10

共 32 条

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