EFFICACY OF AUTOLOGOUS PERITONEUM AS A BIOLOGICAL MEMBRANE IN CARDIAC-SURGERY

被引：10

作者：

PACHOLEWICZ, JK ^{[1
]}

DALOISIO, C ^{[1
]}

SHAWARBY, OA ^{[1
]}

DHARAN, SM ^{[1
]}

GU, J ^{[1
]}

MCGRATH, LB ^{[1
]}

机构：

[1] DEBORAH HEART & LUNG CTR,DEPT SURG,TRENTON RD,BROWNS MILLS,NJ 08015

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1994年 / 8卷 / 10期

关键词：

PERICARDIAL SUBSTITUTE; BIOLOGICAL MEMBRANE; CARDIAC SURGERY;

D O I：

10.1016/1010-7940(94)90077-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The risks for reoperative cardiac surgery are related to the presence of intrapericardial adhesions and the possibility of catastrophic injury at repeat sternotomy. In an attempt to develop an improved pericardial substitute and vascular patch, the feasibility of using autologous peritoneum was evaluated. Twelve mongrel dogs were studied. A peritoneal-rectus fascia patch, including the overlying posterior rectus sheath was harvested, via a lateral abdominal incision, and stored in normal saline. In the first group of six animals, a pulmonary artery (PA) window was created and then closed with the peritoneal-rectus fascia patch. In the second group a secundum atrial septal defect was created and then closed with the peritoneal patch on cardiopulmonary bypass (CPB). In each animal, the peritoneal-rectus fascia patch was used to permit pericardial closure. Autopsies performed at 90 days postoperatively revealed only slight intrapericardial adhesion formation and a mild epicardial reaction. Histological examination of the peritoneal-rectus fascia patches revealed intact morphology with active fibroblasts and smooth muscle cells. Proline C-14 absorption and autoradiography detected viable cells in the implanted patches. These findings suggest that a peritoneal-rectus fascia allograft could be useful as a biological membrane, and as a satisfactory pericardial substitute in the development of strategies to reduce the risk for reoperative cardiac surgery.

引用

页码：563 / 565

页数：3

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