ALPHA-ATRIAL NATRIURETIC PEPTIDE ATTENUATES ETHANOL WITHDRAWAL SYMPTOMS

被引：10

作者：

KOVACS, GL

机构：

[1] Central Laboratory, Markusovszky Teaching Hospital, Szombathely

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 238卷 / 2-3期

基金：

匈牙利科学研究基金会;

关键词：

ETHANOL WITHDRAWAL; ALPHA-ANP (ALPHA-ATRIAL NATRIURETIC PEPTIDE); ANTI-ANP SERUM;

D O I：

10.1016/0014-2999(93)90878-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mice were rendered tolerant to and dependent on ethanol with an ethanol-liquid diet for 14 days. Five hours after withdrawal from ethanol, withdrawal symptoms were analyzed by scoring handling-induced convulsions. Intracerebroventricular (i.c.v.) injection of alpha-atrial natriuretic peptide (alpha-ANP) attenuated, whereas that of an antiserum against alpha-ANP (anti-ANP) intensified the severity of handling-induced convulsions.

引用

页码：417 / 419

页数：3

共 10 条

[1] ALPHA-ATRIAL NATRIURETIC PEPTIDE, ALDOSTERONE SECRETION AND PLASMA-RENIN ACTIVITY DURING ETHANOL WITHDRAWAL - A CORRELATION WITH THE ONSET OF DELIRIUM-TREMENS [J].