SELECTIVE-INHIBITION OF THE INDUCIBLE NITRIC-OXIDE SYNTHASE BY AMINOGUANIDINE

被引：715

作者：

MISKO, TP ^{[1
]}

MOORE, WM ^{[1
]}

KASTEN, TP ^{[1
]}

NICKOLS, GA ^{[1
]}

CORBETT, JA ^{[1
]}

TILTON, RG ^{[1
]}

MCDANIEL, ML ^{[1
]}

WILLIAMSON, JR ^{[1
]}

CURRIE, MG ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 233卷 / 01期

关键词：

NITRIC OXIDE SYNTHASE; AMINOGUANIDINE; SELECTIVE INHIBITOR INDUCIBLE;

D O I：

10.1016/0014-2999(93)90357-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Overproduction of the free radical nitric oxide (NO) has been implicated in the pathogenesis of a variety of inflammatory and immunologically mediated diseases as well as complications of diabetes. In the present study we have demonstrated that aminoguanidine selectively inhibits the cytokine-inducible isoform of NO synthase which appears to be responsible for the excess production of NO linked to these disease states. By using organ, cell, and enzyme-based measurements we have shown that aminoguanidine is equipotent to N(G)-monomethyl-L-arginine (L-NMA) as an inhibitor of the cytokine-induced isoform of NO synthase but is 10 to 100-fold less potent as an inhibitor of the constitutive isoform. Thus, aminoguanidine may be useful as a selective inhibitor of the inducible NO synthase in the treatment of disease states characterized by the pathological overproduction of NO.

引用

页码：119 / 125

页数：7

共 32 条

[1] ENDOTHELIUM-DEPENDENT INHIBITION OF PLATELET-AGGREGATION [J].