FIBROGENIC CYTOKINES - THE ROLE OF IMMUNE MEDIATORS IN THE DEVELOPMENT OF SCAR TISSUE

被引：537
作者：
KOVACS, EJ
机构：
[1] Dept of Cell Biology, Neurobiology and Anatomy, Loyola University Stritch School of Medicine, Maywood
来源：
IMMUNOLOGY TODAY | 1991年 / 12卷 / 01期
关键词：
D O I：
10.1016/0167-5699(91)90107-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A variety of diseases that are characterized by fibrosis share common features including the proliferation of fibroblasts and the deposition of extracellular matrix. Fibrosis often begins as an inflammatory reaction with leukocyte infiltration followed by the elaboration of cytokines. Here, Elizabeth J. Kovacs argues that the aberrant production of these mediators sustains the connective tissue accumulation that results in permanent alteration in tissue structure and function.
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页码：17 / 23
页数：7
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