PHARMACOLOGICAL STUDIES ON SUFOXAZINE (Y-8894) .1. EFFECTS ON EXPERIMENTAL AMNESIA IN MICE

被引：8
作者：
ANAMI, K
YAMAMOTO, Y
SETOGUCHI, M
机构：
来源：
FOLIA PHARMACOLOGICA JAPONICA | 1985年 / 85卷 / 02期
关键词：
D O I：
10.1254/fpj.85.71
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of sufoxazine on various experimental amnesia models were studied using passive avoidance behavior in mice. Sufoxazine had no influence on learning and memory in intact mice. Sufoxazine, administered either immediately after CO2 exposure or 30 min prior to the acquisition trial, improved CO2 induced amnesia. It also improved both electroconvulsive shock (ECS) induced amnesia (administered immediately after the amnestic treatment) and scopolamine induced amnesia (administered immediately after the acquisition trial). The antidepressant drugs, imipramine and desipramine had no ameliorative activity in any of these experimental amnesia models. Evidently, sufoxazine improves amnesia experimentally induced by various methods.
引用
收藏
页码：71 / 77
页数：7
相关论文
共 28 条
[1]   EFFECT OF CHOLINERGIC AND ANTICHOLINERGIC DRUGS ON SHORT-TERM-MEMORY IN ALZHEIMERS DEMENTIA - A NEUROPSYCHOLOGICAL AND COMPUTERIZED ELECTROENCEPHALOGRAPHIC STUDY [J].
AGNOLI, A ;
MARTUCCI, N ;
MANNA, V ;
CONTI, L ;
FIORAVANTI, M .
CLINICAL NEUROPHARMACOLOGY, 1983, 6 (04) :311-323
[2]   DSP4-INDUCED 2-WAY ACTIVE-AVOIDANCE IMPAIRMENT IN RATS - INVOLVEMENT OF CENTRAL AND NOT PERIPHERAL NORADRENALINE DEPLETION [J].
ARCHER, T ;
OGREN, SO ;
JOHANSSON, G ;
ROSS, SB .
PSYCHOPHARMACOLOGY, 1982, 76 (04) :303-309
[3]   MEMORY FACILITATION WITH POST-TRIAL INJECTION OF OXOTREMORINE AND PHYSOSTIGMINE IN MICE [J].
BARATTI, CM ;
HUYGENS, P ;
MINO, J ;
MERLO, A ;
GARDELLA, J .
PSYCHOPHARMACOLOGY, 1979, 64 (01) :85-88
[4]   EFFECTS OF ANTIMUSCARINIC CHOLINERGIC DRUGS INJECTED SYSTEMICALLY OR INTO THE HIPPOCAMPO-ENTORHINAL AREA UPON PASSIVE-AVOIDANCE LEARNING IN YOUNG-RATS [J].
BLOZOVSKI, D ;
HENNOCQ, N .
PSYCHOPHARMACOLOGY, 1982, 76 (04) :351-358
[5]   QUALITATIVE-ANALYSIS OF SCOPOLAMINE-INDUCED AMNESIA [J].
CAINE, ED ;
WEINGARTNER, H ;
LUDLOW, CL ;
CUDAHY, EA ;
WEHRY, S .
PSYCHOPHARMACOLOGY, 1981, 74 (01) :74-80
[6]   EFFECTS OF CHLORPROMAZINE AND IMIPRAMINE ON DISCRIMINATION-LEARNING, CONSOLIDATION, AND LEARNED BEHAVIOR IN 2 INBRED STRAINS OF MICE [J].
CASTELLANO, C .
PSYCHOPHARMACOLOGY, 1977, 53 (01) :27-31
[7]  
CHISTIE JE, 1981, BRIT J PSYCHIAT, V138, P46
[8]  
CHONEIM MM, 1977, PSYCHOPHARMACOLOGY B, V52, P1
[9]   PIRACETAM IN ELDERLY PSYCHIATRIC-PATIENTS WITH MILD DIFFUSE CEREBRAL IMPAIRMENT [J].
CHOUINARD, G ;
ANNABLE, L ;
ROSSCHOUINARD, A ;
OLIVIER, M ;
FONTAINE, F .
PSYCHOPHARMACOLOGY, 1983, 81 (02) :100-106
[10]   PRE-TEST EPINEPHRINE INJECTIONS REVERSE DDC-INDUCED RETROGRADE-AMNESIA [J].
CONCANNON, JT ;
CARR, M .
PHYSIOLOGY & BEHAVIOR, 1982, 29 (03) :443-448
123