Association study of fatty acid binding protein 2 gene polymorphism for diabetic nephropathy in Japanese patients with type 2 diabetes

被引：1

作者：

Yoshioka, Keiji ^{[1
]}

Yoshida, Toshihide ^{[2
]}

Kogure, Akinori ^{[3
]}

Takakura, Yasuto ^{[4
]}

Umekawa, Tsunekazu ^{[5
]}

Toda, Hitoshi ^{[6
]}

机构：

[1] Matsushita Mem Hosp, Dept Endocrinol & Diabet, 5-55 Sotojima Cho, Moriguchi, Osaka, Japan

[2] Kyoto City Hosp, Dept Daibetes & Metab, Kyoto, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan

[4] Kyoto Second Red Cross Hosp, Dept Internal Med, Kyoto, Japan

[5] Umekawa Clin, Kyoto, Japan

[6] Sakazaki Clin, Kyoto, Japan

来源：

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2010年 / 4卷 / 01期

关键词：

FABP2 gene polymorphism; Diabetic nephropathy;

D O I：

10.1016/j.dsx.2010.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To test the hypothesis whether the Ala54Thr polymorphism of the fatty acid binding protein 2 (FABP2) gene was associated with diabetic nephropathy, we studied a total of 397 Japanese type 2 diabetic patients. The diagnosis of diabetic nephropathy was based on measurements of urinary albumin: creatinine ratio (ACR). We subdivided subjects as those with normoalbuminuria (ACR < 30 mg/g Cr), those with micro- albuminuria (ACR:30-300 mg/g Cr), and those with macroalbuminuria (ACR (3)300 mg/g Cr). FABP2 genotypes were determined with a fluorescent allele-specific DNA primer assay system. The results showed that the genotypes of Ala54Thr polymorphism of the FABP2 gene were not significantly different among normo-, micro- and macro-albuminuria groups, suggesting that polymorphism of this gene was not associated with diabetic nephropathy in Japanese type 2 diabetic subjects. (C) 2010 Diabetes India. Published by Elsevier Ltd. All rights reserved.

引用

页码：18 / 20

页数：3

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