STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN ANTI-MULLERIAN HORMONE TYPE-II RECEPTOR GENE

被引：25
|
作者：
VISSER, JA [1 ]
MCLUSKEY, A [1 ]
VANBEERS, T [1 ]
WEGHUIS, DO [1 ]
VANKESSEL, AG [1 ]
GROOTEGOED, JA [1 ]
THEMMEN, APN [1 ]
机构：
[1] UNIV NIJMEGEN HOSP,DEPT HUMAN GENET,6500 HB NIJMEGEN,NETHERLANDS
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 03期
关键词：
D O I：
10.1006/bbrc.1995.2567
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using the rat anti-mullerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent mullerian duct syndrome. (C) 1995 Academic Press, Inc.
引用
收藏
页码：1029 / 1036
页数：8
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