BENZODIPYRAN DERIVATIVES WITH ANTIALLERGIC ACTIVITY

被引：26

作者：

BANTICK, JR ^{[1
]}

CAIRNS, H ^{[1
]}

CHAMBERS, A ^{[1
]}

HAZARD, R ^{[1
]}

KING, J ^{[1
]}

LEE, TB ^{[1
]}

MINSHULL, R ^{[1
]}

机构：

[1] FISONS LTD, RES & DEV LABS, DIV PHARM, LOUGHBOROUGH, LEICESTERSHIRE, ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1976年 / 19卷 / 06期

关键词：

D O I：

10.1021/jm00228a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antiallergic activity of a number of benzodipyrandicarboxylic acids are described. Antiallergic activity of the compounds was determined using the homologous passive cutaneous anaphylaxis (PCA) reaction in the rat. The structural requirements for activity in the PCA screen are discussed. In this test system the linear benzodipyrans are more active than their angular analogs.

引用

页码：817 / 821

页数：5

共 26 条

[11]

DESAI RD, 1938, P INDIAN ACAD SCI, VA8, P194

[12] BENZOPYRONES .7. SYNTHESIS AND ANTIALLERGIC ACTIVITY OF SOME 2-(5-TETRAZOLYL) CHROMONES [J].

ELLIS, GP ;

SHAW, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (08) :865-&

[13]

EVANS DP, 1974, NATURE, V250, P593

[14]

GOOSE J, 1969, IMMUNOLOGY, V16, P749

[15]

GULATI KC, 1931, J CHEM SOC, P2376

[16] QUINOLINE DERIVATIVES AS ANTIALLERGY AGENTS [J].

HALL, CM ;

JOHNSON, HG ;

WRIGHT, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (07) :685-690

[17]

LILLE J, 1969, EESTI NSV TEAD AKAD, V18, P365

[18]

LIMAYE SD, 1943, RASAYANAM, V1, P246

[19]

LOBOTAN P, UNPUBLISHED RESULTS

[20]

MISRA GC, 1968, INDIAN J CHEM, V6, P338

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