Regulation of TGF-beta Signal Transduction

被引：25
|
作者：
Bing Zhao [1 ]
Ye-Guang Chen [1 ]
机构：
[1] Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
来源：
SCIENTIFICA | 2014年 / 2014卷
关键词：
D O I：
10.1155/2014/874065
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Transforming growth factor-beta (TGF-beta) signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity, and migration. TGF-beta signaling can be mediated by Smad proteins or other signaling proteins such as MAP kinases and Akt. TGF-beta signaling is tightly regulated at different levels along the pathways to ensure its proper physiological functions in different cells and tissues. Deregulation of TGF-beta signaling has been associated with various kinds of diseases, such as cancer and tissue fibrosis. This paper focuses on our recent work on regulation of TGF-beta signaling.
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页数：9
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