ENHANCED MYCN EXPRESSION AND ISOCHROMOSOME 17Q IN PINEALOBLASTOMA CELL-LINES

被引：22
作者：
KEES, UR
BIEGEL, JA
FORD, J
RANFORD, PR
PERONI, SE
HALLAM, LA
PARMITER, AH
WILLOUGHBY, MLN
SPAGNOLO, D
机构：
[1] PRINCESS MARGARET HOSP CHILDREN,DEPT HAEMATOL ONCOL,PERTH,WA,AUSTRALIA
[2] PRINCESS MARGARET HOSP CHILDREN,DEPT ANAT PATHOL,PERTH,WA,AUSTRALIA
[3] CHILDRENS HOSP PHILADELPHIA,DIV HUMAN GENET,PHILADELPHIA,PA 19104
[4] QUEEN ELIZABETH II MED CTR,HOSP PATHOL SERV,PERTH,WA,AUSTRALIA
[5] QUEEN ELIZABETH II MED CTR,UNIV PATHOL SERV,PERTH,WA,AUSTRALIA
来源：
GENES CHROMOSOMES & CANCER | 1994年 / 9卷 / 02期
关键词：
D O I：
10.1002/gcc.2870090209
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have established two cell lines, PER-452 and PER-453, from an 8-month-old girl with an extensive pineoblastoma. Characterization of these lines revealed that the proto-oncogenes MYC and MYCN were not amplified, but both cell lines showed MYCN expression comparable to a cell line with 200-fold MYCN amplification. Both cell lines contained an i(17q). These results support the concept that pineoblastomas belong to a larger group of primitive neuroectodermal tumors of the central nervous system. These two cell lines provide a unique opportunity to investigate the molecular genetic mechanisms underlying these neoplasms further. (C) 1994 Wiley-Liss, Inc.
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收藏
页码：129 / 135
页数：7
相关论文
共 44 条
  • [1] AMBROS IM, 1991, CANCER, V67, P1886, DOI 10.1002/1097-0142(19910401)67:7<1886::AID-CNCR2820670712>3.0.CO
  • [2] 2-U
  • [3] THE MIC2 GENE-PRODUCT - EPITOPE MAPPING AND STRUCTURAL PREDICTION ANALYSIS DEFINE AN INTEGRAL MEMBRANE-PROTEIN
    BANTING, GS
    PYM, B
    DARLING, SM
    GOODFELLOW, PN
    [J]. MOLECULAR IMMUNOLOGY, 1989, 26 (02) : 181 - 188
  • [4] BIEGEL JA, 1992, CANCER RES, V52, P3391
  • [5] ISOCHROMOSOME-17Q IN PRIMITIVE NEUROECTODERMAL TUMORS OF THE CENTRAL-NERVOUS-SYSTEM
    BIEGEL, JA
    RORKE, LB
    PACKER, RJ
    SUTTON, LN
    SCHUT, L
    BONNER, K
    EMANUEL, BS
    [J]. GENES CHROMOSOMES & CANCER, 1989, 1 (02) : 139 - 147
  • [6] STRUCTURAL CHROMOSOMAL-ABNORMALITIES IN HUMAN MEDULLOBLASTOMA
    BIGNER, SH
    MARK, J
    FRIEDMAN, HS
    BIEGEL, JA
    BIGNER, DD
    [J]. CANCER GENETICS AND CYTOGENETICS, 1988, 30 (01) : 91 - 101
  • [7] BIGNER SH, 1990, CANCER RES, V50, P2347
  • [8] BORIT A, 1980, CANCER-AM CANCER SOC, V45, P1408, DOI 10.1002/1097-0142(19800315)45:6<1408::AID-CNCR2820450619>3.0.CO
  • [9] 2-0
  • [10] A DER(11)T(8,11) IN 2 MEDULLOBLASTOMAS - A POSSIBLE NONRANDOM CYTOGENETIC ABNORMALITY
    CALLEN, DF
    CIROCCO, L
    MOORE, L
    [J]. CANCER GENETICS AND CYTOGENETICS, 1989, 38 (02) : 255 - 260
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