THE DISTRIBUTION OF HISTIDINE-DECARBOXYLASE MESSENGER-RNA IN THE RAT-BRAIN - AN INSITU HYBRIDIZATION STUDY USING SYNTHETIC OLIGONUCLEOTIDE PROBES

被引：31

作者：

CASTREN, E ^{[1
]}

PANULA, P ^{[1
]}

机构：

[1] UNIV HELSINKI, DEPT ANAT, SILTAVUORENPENGER 20A, SF-00170 HELSINKI 17, FINLAND

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 01期

基金：

英国医学研究理事会; 芬兰科学院;

关键词：

Histamine; Histidine decarboxylase; In situ hybridization; Rat; Tuberomammillary nucleus;

D O I：

10.1016/0304-3940(90)90181-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

l-Histidine decarboxylase catalyzes the formation of histamine from the amino acid l-histidine. We have studied the distribution of neurons expressing mRNA for histidine decarboxylase in adult rat brain using in situ hybridization with synthetic oligonucleotide probes. The expression of mRNA for histidine decarboxylase was detected in the hypothalamic tuberomammillary nucleus that has been shown to contain histidine decarboxylase-like and histamine-like immunoreactivity, but not in any other brain area. This method may prove useful in studying the physiological role of central histaminergic neurons. © 1990.

引用

页码：113 / 116

页数：4

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