SINDBIS VIRUS MUTANTS SELECTED FOR RAPID GROWTH IN CELL-CULTURE DISPLAY ATTENUATED VIRULENCE IN ANIMALS

被引:65
作者
OLMSTED, RA [1 ]
BARIC, RS [1 ]
SAWYER, BA [1 ]
JOHNSTON, RE [1 ]
机构
[1] N CAROLINA STATE UNIV, DEPT MICROBIOL, RALEIGH, NC 27695 USA
关键词
D O I
10.1126/science.6204381
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:424 / 427
页数:4
相关论文
共 32 条
[11]   AN ATTENUATED MUTANT OF VENEZUELAN ENCEPHALITIS-VIRUS - BIOCHEMICAL-ALTERATIONS AND THEIR GENETIC ASSOCIATION WITH ATTENUATION [J].
EMINI, EA ;
WIEBE, ME .
VIROLOGY, 1981, 110 (01) :185-196
[12]   MOLECULAR-BASIS OF REOVIRUS VIRULENCE [J].
FIELDS, BN .
ARCHIVES OF VIROLOGY, 1982, 71 (02) :95-107
[13]   GENETIC AND MOLECULAR MECHANISMS OF VIRAL PATHOGENESIS - IMPLICATIONS FOR PREVENTION AND TREATMENT [J].
FIELDS, BN ;
GREENE, MI .
NATURE, 1982, 300 (5887) :19-23
[14]  
GAROFF H, 1982, CURR TOP MICROBIOL, V99, P1
[15]  
JOHNSON RT, 1965, AM J PATHOL, V46, P929
[16]   AGE-DEPENDENT RESISTANCE TO VIRAL ENCEPHALITIS - STUDIES OF INFECTIONS DUE TO SINDBIS VIRUS IN MICE [J].
JOHNSON, RT ;
MCFARLAND, HF ;
LEVY, SE .
JOURNAL OF INFECTIOUS DISEASES, 1972, 125 (03) :257-+
[17]   CORRELATION OF MESSENGER-RNA FUNCTION WITH ADENYLATE-RICH SEGMENTS IN GENOMES OF SINGLE-STRANDED RNA VIRUSES [J].
JOHNSTON, RE ;
BOSE, HR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (06) :1514-&
[18]  
Kennett R. H., 1980, MONOCLONAL ANTIBODIE, P376
[19]   TEMPERATURE-SENSITIVE HOST-DEPENDENT MUTANTS OF SINDBIS VIRUS [J].
KOWAL, KJ ;
STOLLAR, V .
VIROLOGY, 1981, 114 (01) :140-148
[20]   CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].
LAEMMLI, UK .
NATURE, 1970, 227 (5259) :680-+