TRANSFORMING GROWTH FACTOR beta 1 AT LIVER TRANSPLANTATION

被引：0
作者：
Kurabekova, R. M.
Shevchenko, O. P.
Tsiroulnikova, O. M.
机构：
[1] Russian Federat, Minist Healthcare, VI Shumakov Fed Res Ctr Transplantol & Artificial, Moscow, Russia
[2] IM Sechenov First Moscow State Med Univ, Russian Federat, Dept transplantol & artificial organs, Moscow, Russia
来源：
VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2015年 / 17卷 / 03期
关键词：
liver transplantation; TGF-beta; 1; biomarkers; cytokines;
D O I：
10.15825/1995-1191-2015-3-76-82
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
This review summarizes the current literature devoted to the analysis of the role of transforming growth factor beta 1 (TGF-beta 1) at liver transplantation. TGF-beta 1 plays a key role in the development of liver fibrosis, as well as in development of the immune response; its concentration in the blood and tissue changes in liver diseases. TGF-beta 1 levels in the blood of the recipients are associated with the development of liver fibrosis, the formation of immune tolerance and immune response to active infection. Measuring the level of TGF-beta 1 at liver transplantation may have diagnostic and prognostic value for assessing the graft condition. Currently, clinical data on the role of the cytokine at liver transplantation are not accumulated enough and further research on the relation of TGF-beta 1 levels with different clinical and laboratory parameters in liver transplant patients is needed. The review analyzed 54 sources of literature, more than half of which were published in the last five years.
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收藏
页码：76 / 82
页数：7
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