A NESTED CASE-CONTROL STUDY ON THE ASSOCIATION BETWEEN HELICOBACTER-PYLORI INFECTION AND GASTRIC-CANCER RISK IN A COHORT OF 9775 MEN IN TAIWAN

被引：0
作者：
LIN, JT
WANG, LY
WANG, JT
WANG, TH
YANG, CS
CHEN, CJ
机构：
[1] NATL TAIWAN UNIV,COLL PUBL HLTH,INST EPIDEMIOL,TAIPEI 10018,TAIWAN
[2] NATL TAIWAN UNIV,COLL MED,DEPT INTERNAL MED,TAIPEI 10018,TAIWAN
[3] NATL TAIWAN UNIV,COLL MED,DEPT BACTERIOL,TAIPEI 10018,TAIWAN
[4] ACAD SINICA,INST BIOMED SCI,TAIPEI,TAIWAN
来源：
ANTICANCER RESEARCH | 1995年 / 15卷 / 02期
关键词：
HELICOBACTER PYLORI; GASTRIC CANCER; NESTED CASE-CONTROL STUDY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A nested case-control study was carried out to investigate the association between Helicobacter pylori infection and gastric cancer risk in Taiwan. A total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9.775 men recruited from 1984 through 1986. Frozen serum samples collected at recruitment examination were tested for IgG antibodies against Helicobacter pylori by an enzyme-linked immunosorbent assayl The average interval between serum collection and cancer diagnosis was 3.1 years. Gastric cancer cased had a higher seropositive prevalence (69%) than matched controls (59%) giving an odds ratio of 1.6 (95% confidence interval = 0.7-2.6). Compared with previous nested case-control studies, Helicobacter pylori infection in early childhood may be a risk factor for gastric cancer. However, a long induction period seems required for gastro-carcinogenesis associated with Helicobacter pylori infection.
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收藏
页码：603 / 606
页数：4
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