A STRAIN THEORY OF MALARIA TRANSMISSION

被引：62

作者：

GUPTA, S

DAY, KP

机构：

[1] Sunetra Gupta and Karen Day are, the Department of Zoology, University of Oxford, Oxford

来源：

PARASITOLOGY TODAY | 1994年 / 10卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0169-4758(94)90160-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Does the fact that the risk of getting malaria is high in most endemic areas mean that it will be impossible to control through vaccination? Not if malaria is composed of several mildly transmissible strains, and what we are measuring as the high risk is the probability of being infected by any one of the several strains circulating independently within the some area. In this article, Sunetra Gupta and Karen Day discuss a strain theory of malaria transmission that fits both recent serologicol and molecular observations and more conventional epidemiological date on age distributions of infection and disease. Their analyses suggest that the transmissibility of malaria has been grossly overestimated and that the control of malaria through vaccination may be far easier than previously assumed.

引用

页码：476 / 481

页数：6

共 38 条

[1]

AGUIAR JC, 1992, AM J TROP MED HYG, V47, P621

[2] A MALARIA CONTROL TRIAL USING INSECTICIDE-TREATED BED NETS AND TARGETED CHEMOPROPHYLAXIS IN A RURAL AREA OF THE GAMBIA, WEST-AFRICA .6. THE IMPACT OF THE INTERVENTIONS ON MORTALITY AND MORBIDITY FROM MALARIA [J].