THE EFFECTS OF TRIFLUOPERAZINE ON CALCIFYING TISSUES IN THE IMMATURE RAT

被引：0
作者：
BOSKEY, AL [1 ]
LEWINSON, D [1 ]
BULLOUGH, PG [1 ]
机构：
[1] TECHNION ISRAEL INST TECHNOL, FAC MED, HAIFA, ISRAEL
来源：
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE | 1984年 / 176卷 / 02期
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D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
When the antipsychotic drug trifluoperazine is given to immature rats during stages of rapid bone development, severe localized derangement in their growth plate architecture results. In addition, 3 wk of treatment with doses of 3 mg/kg body wt per day had marked effects on the anatomic distribution of bone mineral and on the quantitative chemical composition of the bone matrix. Specifically, ash contents and Ca/P ratios were decreased, and mineral crystals appeared larger and/or more perfect in the treated animals. The finding of decreased hexosamine content and alterations in bone lipid composition could be interpreted as specific effects of the drug on calmodulin activity.
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页码：154 / 163
页数：10
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