Stem cells: general aspects, biological and molecular events

被引：0
作者：
Acevedo Toro, Paola Andrea [1 ]
Cortes Marquez, Monica Maria [2 ,3 ]
机构：
[1] Univ Antioquia, Integrante Grp HEMO Hematopatol Mol, Hematol, Medellin, Colombia
[2] Univ Antioquia, Bacteriol Lab Clin, Medellin, Colombia
[3] Univ Antioquia, Escuela Microbiol, Hematol, Medellin, Colombia
来源：
IATREIA | 2008年 / 21卷 / 03期
关键词：
ARF-1; protein; BMI-1; gene; Differentiation; Microenviroment; NANOG gene; Notch receptors; OCT3/; 4; genes; p16(Ink4a) genes; Self-renewal; SOX2; Stem cells; Transcription factors; Wnt proteins;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Self-renewal capacity and differentiation are features of stem cells that vary among the different cellular types according to the tissue in which they reside and the surrounding microenvironment. Cellular cycle inhibitors, genes implied in chromosomal rearrangements, essential development proteins and specific signaling pathways intervene in these processes. Self-renewal is regulated by different mechanisms, the most important of which are the Wnt, Notch and Hedgehog pathways, and the factors BMI-1, p16(Ink4a), ARF, NANOG, OCT3/4, SOX2, HOXB4 and their paralogs. Advances in the knowledge of stem cells biology and of the molecular mechanisms that influence their self-renewal and differentiation have made these cells an important promise for both basic and applied research.
引用
收藏
页码：292 / 306
页数：15
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