SCREENING-TEST OF CRUDE DRUG EXTRACT ON ANTI-HIV ACTIVITY

被引：29
|
作者：
YAMASAKI, K [1 ]
OTAKE, T [1 ]
MORI, H [1 ]
MORIMOTO, M [1 ]
UEBA, N [1 ]
KUROKAWA, Y [1 ]
SHIOTA, K [1 ]
YUGE, T [1 ]
机构：
[1] OSAKA UNIV PHARMACEUT SCI, MATSUBARA, OSAKA 580, JAPAN
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 11期
关键词：
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); ANTIVIRAL ACTIVITY; AIDS; CRUDE DRUG EXTRACT; LITHOSPERMUM ERYTHRORHIZON; PRUNELLA VULGARIS;
D O I：
10.1248/yakushi1947.113.11_818
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 mu g/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.
引用
收藏
页码：818 / 824
页数：7
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