SCREENING-TEST OF CRUDE DRUG EXTRACT ON ANTI-HIV ACTIVITY

被引：29
|
作者：
YAMASAKI, K [1 ]
OTAKE, T [1 ]
MORI, H [1 ]
MORIMOTO, M [1 ]
UEBA, N [1 ]
KUROKAWA, Y [1 ]
SHIOTA, K [1 ]
YUGE, T [1 ]
机构：
[1] OSAKA UNIV PHARMACEUT SCI, MATSUBARA, OSAKA 580, JAPAN
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 11期
关键词：
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1); ANTIVIRAL ACTIVITY; AIDS; CRUDE DRUG EXTRACT; LITHOSPERMUM ERYTHRORHIZON; PRUNELLA VULGARIS;
D O I：
10.1248/yakushi1947.113.11_818
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The anti-HIV-1 effects of 204 crude drugs of common use in Japan were evaluated in vitro. As a result, 45 samples inhibited HIV-1-induced cytopathogenicity in MT-4 cells. In particular, the hot water extracts of Lithospermum erythrorhizon (root) and Prunella vulgaris (spike) showed the strongest anti-HIV-1 activities. Their IC100 values were both 16 mu g/ml. In general, the hot water extracts of the crude drug suppressed the replication of HIV-1 growth more strongly than the cold water extracts.
引用
收藏
页码：818 / 824
页数：7
相关论文
共 50 条
  • [1] Anti-HIV activity of medicinal plant extracts
    Bedoya, LM
    Sanchez-Palomino, S
    Abad, MJ
    Bermejo, P
    Alcami, J
    JOURNAL OF ETHNOPHARMACOLOGY, 2001, 77 (01) : 113 - 116
  • [2] Lymphatic Delivery of Anti-HIV Drug Nanoparticles
    Nayak, Yogendra
    Avadhani, Kiran
    Mutalik, Srinivas
    Nayak, Usha Y.
    RECENT PATENTS ON NANOTECHNOLOGY, 2016, 10 (02) : 116 - 127
  • [3] A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity
    Balzarini, Jan
    Andrei, Graciela
    Balestra, Emanuela
    Huskens, Dana
    Vanpouille, Christophe
    Introini, Andrea
    Zicari, Sonia
    Liekens, Sandra
    Snoeck, Robert
    Holy, Antonin
    Perno, Carlo-Federico
    Margolis, Leonid
    Schols, Dominique
    PLOS PATHOGENS, 2013, 9 (07)
  • [4] Anti-HIV activity of Indian medicinal plants
    Sudeep Sabde
    Hardik S. Bodiwala
    Aniket Karmase
    Preeti J. Deshpande
    Amandeep Kaur
    Nafees Ahmed
    Siddheshwar K. Chauthe
    Keyur G. Brahmbhatt
    Rasika U. Phadke
    Debashis Mitra
    Kamlesh Kumar Bhutani
    Inder Pal Singh
    Journal of Natural Medicines, 2011, 65 : 662 - 669
  • [5] Compounds with anti-HIV activity from plants
    Houghton, PJ
    TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1996, 90 (06) : 601 - 604
  • [6] Anti-HIV activity of Indian medicinal plants
    Sabde, Sudeep
    Bodiwala, Hardik S.
    Karmase, Aniket
    Deshpande, Preeti J.
    Kaur, Amandeep
    Ahmed, Nafees
    Chauthe, Siddheshwar K.
    Brahmbhatt, Keyur G.
    Phadke, Rasika U.
    Mitra, Debashis
    Bhutani, Kamlesh Kumar
    Singh, Inder Pal
    JOURNAL OF NATURAL MEDICINES, 2011, 65 (3-4) : 662 - 669
  • [7] Latest animal models for anti-HIV drug discovery
    Sliva, Katja
    EXPERT OPINION ON DRUG DISCOVERY, 2015, 10 (02) : 111 - 123
  • [8] Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009
    Bruce K. Cassels
    Marcelo Asencio
    Phytochemistry Reviews, 2011, 10 : 545 - 564
  • [9] Structural studies of algal lectins with anti-HIV activity
    Ziolkowska, Natasza E.
    Wlodawer, Alexander
    ACTA BIOCHIMICA POLONICA, 2006, 53 (04) : 617 - 626
  • [10] Topological models for prediction of anti-HIV activity of acylthiocarbamates
    Bajaj, S
    Sambi, SS
    Madan, AK
    BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (09) : 3263 - 3268
12345