EFFECT OF SELECTIVE AND NONSELECTIVE MUSCARINIC BLOCKADE ON CHOLECYSTOKININ-INDUCED GALLBLADDER EMPTYING IN MAN

被引：17

作者：

GARRIGUES, V ^{[1
]}

PONCE, J ^{[1
]}

CANO, C ^{[1
]}

SOPENA, R ^{[1
]}

HOYOS, M ^{[1
]}

DELVAL, A ^{[1
]}

BERENGUER, J ^{[1
]}

机构：

[1] HOSP LA FE,DEPT NUCL MED,E-46009 VALENCIA,SPAIN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1992年 / 37卷 / 01期

关键词：

GALLBLADDER EMPTYING; MUSCARINIC RECEPTORS; ATROPINE; PIRENZEPINE; CHOLECYSTOKININ;

D O I：

10.1007/BF01308350

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In this study we investigated the effect of selective (M1) and non-selective (M1 and M2) pharmacologic blockade of muscarinic receptors on cholecystokinin-induced gallbladder emptying. After validating the method of study, the gallbladder function was evaluated in 15 normal volunteers by quantitative biliary scintigraphy, and the effect of intravenous atropine (0.15 mg/10 kg) and pirenzepine (10 mg) was analyzed in each subject. Atropine significantly reduced the ejection period and the ejection fraction of gallbladder evacuation. Pirenzepine reduced the ejection period, but the ejection fraction remained unchanged. We conclude that the effect of cholecystokinin on gallbladder motility is mediated through muscarinic receptors. Our results suggest that M2 receptors, but not M1 receptors, are involved in this response.

引用

页码：101 / 104

页数：4

共 18 条

[1] EFFECT OF CHOLECYSTOKININ AND THE OCTAPEPTIDE OF CHOLECYSTOKININ ON THE FELINE SPHINCTER OF ODDI AND GALLBLADDER - MECHANISMS OF ACTION [J].