A case of adult atypical haemolytic uraemic syndrome related to anti-factor H autoantibodies successfully treated by plasma exchange, corticosteroids and rituximab

被引：18
作者：
Lionet, Arnaud [1 ]
Provot, Francois [1 ]
Glowacki, Francois [1 ]
Fremeaux-Bacchi, Veronique [2 ]
Hazzan, Marc [1 ]
机构：
[1] CHRU Lille, Hosp Calmette, Dept Nephrol, Lille, France
[2] Hop Europeen Georges Pompidou, Dept Immunol, Paris, France
来源：
CLINICAL KIDNEY JOURNAL | 2009年 / 2卷 / 06期
关键词：
anti-CFH autoantibodies; atypical HUS; plasma exchange; rituximab;
D O I：
10.1093/ndtplus/sfp109
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Complement factor H auto-antibodies (CFH-ab) are a rare cause (6-10%) of atypical haemolytic uraemic syndrome (aHUS). All observations previously described were retrospective and occurred in children or teenagers. We report the first case of aHUS associated with anti-CFH antibodies in an adult patient who was successfully treated by plasma exchange, corticosteroids and rituximab.
引用
收藏
页码：458 / 460
页数：3
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