LIPOPROTEIN-LIPASE AND HORMONE-SENSITIVE LIPASE ACTIVITIES IN HUMAN SUBCUTANEOUS LIPOMAS - COMPARISON WITH NORMAL SUBCUTANEOUS ADIPOSE-TISSUE

Lipoprotein lipase activity and hormone-sensitive lipase activity were investigated in subcutaneous lipomas removed from 2 patients and compared with the enzyme activities in subcutaneous adipose tissue from 2 normal subjects. Confirmation was obtained of the presence of lipoprotein lipase activity in lipomas with an activity 15-45.times. that in the 2 control samples. Hormone-sensitive lipase activity was demonstrated in lipomas under basal conditions of assay and in the presence of adrenaline plus theophylline. However, compared with the non-lipomatous fat samples, these activities were lower, as was the magnitude of the lipolytic response to adrenaline plus theophylline. The significance of these measurements of enzyme activity and their role in the pathogenesis of lipomas are briefly discussed.