EFFECTS OF BIOLOGICALLY-ACTIVE TUMOR-PROMOTING AND NONPROMOTING PHORBOL ESTERS ON INVITRO GROWTH OF MELANOCYTIC CELLS

被引:15
作者
BROOKS, G
BIRCH, M
HART, IR
机构
[1] Biology of Metastasis Laboratory, Imperial Cancer Research Fund, London
来源
PIGMENT CELL RESEARCH | 1990年 / 3卷 / 02期
关键词
Melanin; Mitogenesis; Protein kinase C;
D O I
10.1111/j.1600-0749.1990.tb00328.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Sapintoxin A (SAP A), a naturally occurring biologically active but non‐promoting phorbol ester, acts as an effective in vitro mitogen for freshly derived human melanocytes. Seven days after addition of 50 nM SAP A there was a four to fivefold increase in melanocyte number over that observed in untreated control cultures comparable to that achieved with a 50 nM concentration of 12‐0‐tetradecanoylphorbol 13‐acetate (TPA). The fluorescent stage 2 promoter sapintoxin D (SAP D) also supported the growth of these cells, with a 50 nM dose producing an increase in cell number comparable to that observed with 200 nM TPA. Similar results were obtained with an established, but non‐tumorigenic, line of murine melanocytes. The same compounds exerted a potent anti‐proliferative effect against transformed melanocyte lines of murine and human origin associated with morphological alterations and an increase in melanin production consistent with induced cytodifferentiation. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码:98 / 100
页数:3
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