VASCULAR REACTIVITY IN CHRONIC GOLDBLATT 2 KIDNEY ONE CLIP HYPERTENSIVE RATS

被引：2

作者：

DUARTE, J

ANDRADE, J

VARGAS, F

机构：

[1] Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Granada

来源：

EXPERIENTIA | 1990年 / 46卷 / 08期

关键词：

angiotensin; Goldblatt two kidney-one clip hypertension; noradrenaline; vascular reactivity; vasopresin;

D O I：

10.1007/BF01935541

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We studied the possible contribution of increased vascular reactivity in the chronic phase of Goldblatt two kidney-one clip hypertension. Vascular reactivity was evaluated in aortic strips from hypertensive rats (16 weeks after inducing hypertension) and age-matched control rats. The findings were: a) increased sensitivity to vasopressin in the aortic tissue of hypertensive rats, b) a similar response to angiotensin II, noradrenaline and KCl in hypertensive and control rats, and c) reduced maximal response to angiotensin II compared with other vasoconstrictors in both groups of rats. These results suggest a possible role for vasopressin in the chronic phase of this model of hypertension. © 1990 Birkhäuser Verlag Basel.

引用

页码：868 / 869

页数：2

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