THE ROLE OF ATRIAL-NATRIURETIC-PEPTIDE (ANP) IN CHRONIC LIVER-DISEASE

被引：16
作者：
GERBES, AL
机构：
[1] Department of Internal Medicine II, Klinikum Grosshadern, University of Munich
来源：
PHARMACOLOGY & THERAPEUTICS | 1993年 / 58卷 / 03期
关键词：
D O I：
10.1016/0163-7258(93)90028-C
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The role of atrial natriuretic peptide (ANP) and potential defects of ANP in liver disease are reviewed. Patients with cirrhosis of the liver show no decrease of ANP plasma concentrations nor changes in the pattern of ANP immunoreactivity nor changes of splanchnic ANP clearance. The renal effects of exogenously administered as well as endogenously released ANP are blunted in cirrhosis, in particular in patients with ascites. This seems due to increased activity of sodium-retaining hormonal systems and changes of the renal ANP receptor status. Pharmacological inhibition of ANP-degradation or clearance may yield therapeutic potential.
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页码：381 / 390
页数：10
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