DEXTRAN PERMEATION THROUGH POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS

被引：37
|
作者：
DONG, LC [1 ]
HOFFMAN, AS [1 ]
YAN, Q [1 ]
机构：
[1] UNIV WASHINGTON,CTR BIOENGN FL20,SEATTLE,WA 98195
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 1994年 / 5卷 / 05期
关键词：
FITC-DEXTRAN; PERMEATION; HYDROGEL; PORE SIZE; POLY(N-ISOPROPYLACRYLAMIDE); DIFFUSION; THERMALLY REVERSIBLE;
D O I：
10.1163/156856294X00158
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The permeation of macromolecules such as fluoroescein-labeled dextran fractions through thermally reversible hydrogels has been investigated. A permeation model has been formulated, which takes into account hydrogel porosity and tortuosity as well as the combined effect of a geometric restraint for a relatively large solute molecule at a pore entrance and the friction between solute molecules moving through the pores and pore walls. Based on this model, we have estimated the tortuosity and average pore size of a swollen hydrogel, poly(N-isopropylacrylamide) [poly(NIPAAm)] and a swollen heterogel, poly(N-isopropylacrylamide-co-vinyl-terminated dimethylsiloxane) [poly(NIPAAm-co-VTPDMS)]. The permeation data for dextran molecules up to the size of 43.5 Angstrom in radius show good agreement with the values predicted from the model.
引用
收藏
页码：473 / 484
页数：12
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