ASCENDING MYELOPATHY AFTER CHEMOTHERAPY FOR CENTRAL NERVOUS-SYSTEM ACUTE LYMPHOBLASTIC-LEUKEMIA - CORRELATION WITH CEREBROSPINAL-FLUID MYELIN BASIC-PROTEIN

被引：24
作者：
BATES, SE
RAPHAELSON, MI
PRICE, RA
MCKEEVER, P
COHEN, S
POPLACK, DG
机构：
[1] NCI, PEDIAT BRANCH, BLDG 10, ROOM 13N240, BETHESDA, MD 20205 USA
[2] NINCDS, CLIN DIRECTORS OFF, BETHESDA, MD 20205 USA
[3] METHODIST HOSP, DEPT PATHOL, MEMPHIS, TN 38104 USA
[4] UNIV MICHIGAN, SCH MED, DEPT PATHOL, ANN ARBOR, MI 48104 USA
[5] JOHNS HOPKINS UNIV, DEPT NEUROL, BALTIMORE, MD 21218 USA
来源：
MEDICAL AND PEDIATRIC ONCOLOGY | 1985年 / 13卷 / 01期
关键词：
D O I：
10.1002/mpo.2950130103
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ascending myelopathy developed in a previously irradiated 10-yr-old boy after intraventricualr methotrexate and cytosine arabinoside were given for CNS relapse of acute lymphoblastic leukemia. The course was fatal in 10 wk. CSF myelin basic protein levels, indicating a demyelinative process, rose prior to the onset of clinical symptoms and remained at very high levels until death. Myelin basic protein may be useful as a predictor of chemotherapy-associated neurotoxicity.
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页码：4 / 8
页数：5
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