ASPERGILLUS SPECIES STRAIN M39 PRODUCES 2 NAPHTHO-GAMMA-PYRONES THAT REVERSE DRUG-RESISTANCE IN HUMAN KB-CELLS

被引：34
作者：
IKEDA, S
SUGITA, M
YOSHIMURA, A
SUMIZAWA, T
DOUZONO, H
NAGATA, Y
AKIYAMA, S
机构：
[1] KAGOSHIMA UNIV,FAC MED,INST CANC RES,DEPT CANC CHEMOTHERAPY,1208-1 USUKI CHO,KAGOSHIMA 890,JAPAN
[2] KAGOSHIMA UNIV,FAC MED,DEPT OBSTET & GYNECOL,KAGOSHIMA 890,JAPAN
[3] NISSHIN FLOUR MILLING CO LTD,RES CTR,SAITAMA 534,JAPAN
来源：
INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 03期
关键词：
D O I：
10.1002/ijc.2910450323
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
One thousand fungi and Actinomycetes were investigated to see whether they produced compounds that reverse multidrug resistance in KB cells. Only one Aspergillus strain M39 produced agents with resistance‐reversing activity and these compounds were identified to be rubrofusarin B and dianhydro‐aurasperone C. Rubrofusarin B only slightly reversed the resistance of KB‐C2 cells to Adriamycin and daunomycin, partially reversed the resistance to chromomycin A3, and almost completely reversed the resistance to vincristine and mitomycin C. Purified dianhydro‐aurasperone C and rubrofusarin B had similar effects on drug resistance in KB‐8‐5 cells. Dianhydro‐aurasperone C enhanced the accumulation of vinblastine in KB‐8‐5 cells and inhibited the efflux of vinblastine from the cells. Dianhydro‐aurasperone C and rubrofusarin B at 10 μ M completely inhibited 3H‐azidopine photolabelling of P‐glycoprotein. The two products of Aspergillus strain M39 appear to reverse multi‐drug resistance by interacting with P‐glycoprotein and inhibiting its role as an active efflux pump. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：508 / 513
页数：6
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