The novel role of epigenetics in primary prevention of cardiovascular diseases

被引：4

作者：

Napoli, Claudio ^{[1
,2
,3
,4
]}

Casamassimi, Amelia ^{[1
,2
]}

Grimaldi, Vincenzo ^{[3
]}

Schiano, Concetta ^{[1
,2
]}

Infante, Teresa ^{[4
]}

Zullo, Alberto ^{[5
,6
]}

Montesano, Maria Lourdes ^{[3
]}

Auriemma, Laura ^{[3
]}

De Luca, Francesco Paolo ^{[3
]}

De Iorio, Gustavo ^{[3
]}

Ignarro, Louis J. ^{[7
]}

Mancini, Francesco Paolo ^{[5
,8
]}

机构：

[1] Univ Naples 2, Sch Med 1, Dept Gen Pathol, Div Clin Pathol, Caserta, Italy

[2] Univ Naples 2, Excellence Res Ctr Cardiovasc Dis, Sch Med 1, Caserta, Italy

[3] Univ Naples 2, Sch Med 1, Reg Reference Lab Transplant Immunol LIT, UOC Immunohematol Transfus Med & Transplant Immun, Caserta, Italy

[4] IRCCS, Fdn SDN, Bari, Italy

[5] Univ Sannio, Dept Sci Biol Geol & Environm, Benevento, Italy

[6] CEINGE Biotecnol Avanzate SCARL, Naples, Italy

[7] Univ Calif Los Angeles, Ctr Hlth Sci, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90024 USA

[8] Univ Naples Federico II, Dept Biochem & Med Biotechnol, Naples, Italy

来源：

CARDIOGENETICS | 2012年 / 2卷 / 01期

关键词：

epigenetics; cardiovascular disease; primary prevention; hypercholesterolemia; novel; risk factors;

D O I：

10.4081/cardiogenetics.2012.e12

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A great deal of evidences indicate that impaired fetal growth and in utero exposure to risk factors, especially maternal hypercholesterolemia, may be relevant for human pathophysiological signs of atherosclerosis and subsequent development of cardiovascular disease (CVD) during different life stages. Despite the underlying mechanisms of fetal programming are still unknown, epigenetics has been suggested as one of the possible explanations for the associations between intrauterine risk factors and CVD development. Indeed, a lot of translational studies support the hypothesis that epigenetic changes are related to increased CVD risk although it is still not possible to establish a direct causality in humans. Notably, epigenetic modifications can be reversible through therapeutic approaches employing histone deacetylase inhibitors, histone acetyltransferase inhibitors and commonly used drugs like statins. Thus, the whole comprehension of these mechanisms will provide in the next future the rationale for the development of novel tools to be used in the primary prevention and therapy of CVD.

引用

页码：59 / 64

页数：6

共 76 条

[1] Prenatal Exposure to apoE Deficiency and Postnatal Hypercholesterolemia Are Associated with Altered Cell-Specific Lysine Methyltransferase and Histone Methylation Patterns in the Vasculature [J].