GENETIC RISK OF NEUROPSYCHOLOGICAL IMPAIRMENT IN SCHIZOPHRENIA - A STUDY OF MONOZYGOTIC TWINS DISCORDANT AND CONCORDANT FOR THE DISORDER

被引:130
作者
GOLDBERG, TE
TORREY, EF
GOLD, JM
BIGELOW, LB
RAGLAND, RD
TAYLOR, E
WEINBERGER, DR
机构
[1] Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Washington, DC 20032, 2700 Martin Luther King Jr. Ave., SE
关键词
GENETIC RISK; MONOZYGOTIC TWINS; NEUROPSYCHOLOGICAL IMPAIRMENT; (SCHIZOPHRENIA);
D O I
10.1016/0920-9964(95)00032-H
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
We used a paradigm involving monozygotic (MZ) twin pairs discordant for schizophrenia (n=20) and concordant for schizophrenia (n=8), as well as normal MZ twin pairs (n=7) in order to study cognitive measures of genetic risk in schizophrenia. A comparison between the unaffected twins from the discordant sample and the normal twins indicated subtle attenuations in some aspects of memory and executive functioning in the unaffected group and thus provided evidence for cognitive markers of a genetic component in schizophrenia. A comparison of the affected twins from the discordant pairs and the concordant twins yielded virtually no differences, suggesting that a distinction between familial and sporadic cases is not valid in this sample. Large differences between unaffected and affected members of discordant pairs on a wide variety of variables, including IQ, attention, memory, and executive function, highlighted the magnitude of disease-specific factors.
引用
收藏
页码:77 / 84
页数:8
相关论文
共 50 条
  • [41] Neuropsychological deficits in major depression reflect genetic/familial risk more than clinical history: A monozygotic discordant twin-pair study
    Hsu, Kean J.
    Young-Wolff, Kelly C.
    Kendler, Kenneth S.
    Halberstadt, Lisa J.
    Prescott, Carol A.
    PSYCHIATRY RESEARCH, 2014, 215 (01) : 87 - 94
  • [42] T-cell receptor repertoire analysis in monozygotic twins concordant and discordant for type 1 diabetes
    Fozza, Claudio
    Contini, Salvatore
    Corda, Giovanna
    Virdis, Patrizia
    Galleu, Antonio
    Bonfigli, Silvana
    Pacifico, Adolfo
    Maioli, Mario
    Mastinu, Francesco
    Pitzalis, Maristella
    Cucca, Francesco
    Longinotti, Maurizio
    IMMUNOBIOLOGY, 2012, 217 (09) : 920 - 925
  • [43] Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Pol, HEH
    Brans, RGH
    van Haren, NEM
    Schnack, HG
    Langen, M
    Baar, WFC
    van Oel, CJ
    Kahn, RS
    BIOLOGICAL PSYCHIATRY, 2004, 55 (02) : 126 - 130
  • [44] Proteomic Analysis of Lymphoblastoid Cells Derived from Monozygotic Twins Discordant for Bipolar Disorder: A Preliminary Study
    Kazuno, An-a
    Ohtawa, Kenji
    Otsuki, Kaori
    Usui, Masaya
    Sugawara, Hiroko
    Okazaki, Yuji
    Kato, Tadafumi
    PLOS ONE, 2013, 8 (02):
  • [45] A longitudinal study on language acquisition in monozygotic twins concordant for autism and hyperlexia
    Ostrolenk, Alexia
    Courchesne, Valerie
    Mottron, Laurent
    BRAIN AND COGNITION, 2023, 173
  • [46] VarScan2 analysis of de novo variants in monozygotic twins discordant for schizophrenia
    Reble, Emma
    Castellani, Christina A.
    Melka, Melkaye G.
    O'Reilly, Richard
    Singh, Shiva M.
    PSYCHIATRIC GENETICS, 2017, 27 (02) : 62 - 70
  • [47] Coping Styles in Twins Discordant for Schizophrenia, Bipolar Disorder, and Depression
    Fortgang, Rebecca G.
    Hultman, Christina M.
    Cannon, Tyrone D.
    CLINICAL PSYCHOLOGICAL SCIENCE, 2016, 4 (02) : 216 - 228
  • [48] (Epi)genomics and neurodevelopment in schizophrenia: monozygotic twins discordant for schizophrenia augment the search for disease-related (epi)genomic alterations
    Singh, Shiva M.
    O'Reilly, Richard
    GENOME, 2009, 52 (01) : 8 - 19
  • [49] Monozygotic twins discordant for attention-deficit/hyperactivity disorder: Ascertainment and clinical characteristics
    Sharp, WS
    Gottesman, RF
    Greenstein, DK
    Ebens, CL
    Rapoport, JL
    Castellanos, FX
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2003, 42 (01) : 93 - 97
  • [50] Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
    C C Y Wong
    E L Meaburn
    A Ronald
    T S Price
    A R Jeffries
    L C Schalkwyk
    R Plomin
    J Mill
    Molecular Psychiatry, 2014, 19 : 495 - 503